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A mixture of 3.7 g (14 mmol) of the epoxide 11, 26.8 g (0.59 mol) of anhydrous dimethylamine, and 50 ml of EtOH was heated at 100° C. in a stainless steel autoclave for 12 hrs. When cool the contents were removed and concentrated under reduced pressure. Recrystallization of the solid residue from aqueous EtOH afforded 1.6 g (37% yield) of the crystalline amino-diol 12, m.p. 144°-146° C.

1. temperatureWhen cool the contents
2. customwere removed
3. concentrationconcentrated under reduced pressure
4. customRecrystallization of the solid residue from aqueous EtOH