HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Indole, 5-bromo-3-(dimethylamino)methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 5-Bromoindole | HCID 24905 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Indole, 5-bromo-3-(dimethylamino)methyl- | HCID 13249 | — |
Reaction Steps
This material was prepared by the method of Procedure 10B from 49.5 g. of 5-bromoindole, 20 ml. of 37% aqueous formaldehyde, 55 ml. of 25% aqueous dimethylamine, 250 ml. of acetic acid and 250 ml. of dioxane; yield 60.6 g., m.p. 154°-156° C. The structure was confirmed by examination of the NMR spectrum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04495352 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-9cbc4ca81cef41d9a1c030ea57cf3cbf |
| Source note | uspto-grants-1985_01 |