Isopropylamine → HCID 54263101, compound

HRID 2413065Notes

Reaction equation

HRID 2413065 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([N:5]([CH2:12][P:13]([O:17]Cl)([O:15]Cl)=[O:14])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:4].[CH:21]([NH2:24])([CH3:23])[CH3:22]>CCOCC>[F:1][C:2]([F:20])([F:19])[C:3]([N:5]([CH2:12][P:13]([O:17][NH:24][CH:21]([CH3:23])[CH3:22])([O:15][NH:24][CH:21]([CH3:23])[CH3:22])=[O:14])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:4]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 23345669Ethyl N-trifluoroacetyl-N-(dichlorophosphonomethyl)glycinate

Product 1

HCID 54263101HCID 54263101, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of ethyl N-trifluoroacetyl-N-(dichlorophosphonomethyl)glycinate (6.6 g, 0.02 mole) in 200 ml. of ether was added dropwise with good stirring isopropylamine (4.9 g, 0.08 mole) in 70 ml. of ether. The reaction temperature was controlled by cold water bath. The reaction was stirred at room temperature overnight, then was filtered and the filtrate concentrated in vacuo. The residue was taken up in ether, washed with water, dried, concentrated in vacuo, extracted into hot petroleum ether and concentrated to give ethyl N-trifluoroacetyl-N-(bis(isopropylamino)phosphonomethyl)-glycinate as a light yellow oil-gum, ND =1.4495.

Workup

  1. customThe reaction temperature was controlled by cold water bath
  2. filtrationwas filtered
  3. concentrationthe filtrate concentrated in vacuo
  4. washwashed with water
  5. customdried
  6. concentrationconcentrated in vacuo
  7. extractionextracted into hot petroleum ether
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-b1927f0dca1d4a3b86fff2978929b440
Source dataset
uspto-grants-1985_01
Patent number
US04496389

Reaction notes

Loading…