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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2413121Generated: November 1, 2026

Diethyl (ethoxymethylene)malonate → HCID 13290770, compound

https://huagongshe.com/reaction/2413121

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl (ethoxymethylene)malonateHCID 6871—
ReactantHCID 21790133HCID 21790133—
ProductHCID 13290770HCID 1329077086.7%

Reaction Steps

A mixture of 6-amino-2-(4-acetyl-1-piperazinyl)-3-fluoropyridine (23.9 g) and diethyl ethoxymethylenemalonate (22.7 g) is heated for 5 hours with stirring. After cooling, the precipitate is collected by filtration, and recrystallized from ethanol to give 35.5 g of diethyl N-[6-(4-acetyl-1-piperazinyl)-5-fluoro-2-pyridyl)aminomethylenemalonate (m.p. 164°-165° C.).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04496566
Source datasetuspto-grants-1985_01
ORD IDord-b014c61237f04adc894c52ab193cba9d
Source noteuspto-grants-1985_01