Propyl Isothiocyanate → HCID 53930108, compound

HRID 2413138Notes

Reaction equation

HRID 2413138 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:12])[N:3]=1.[CH2:13]([N:16]=[C:17]=[S:18])[CH2:14][CH3:15]>C(#N)C>[CH2:13]([NH:16][C:17](=[S:18])[NH:1][C:2]1[CH:6]=[CH:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:12])[N:3]=1)[CH2:14][CH3:15]

Participants

4

Reactant 2

HCID 69403Propyl IsothiocyanateHCID 13883776HCID 13883776, compound

Product 1

HCID 53930108HCID 53930108, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 5-(3-aminopyrazol-1-yl)valeronitrile (1.0 g.) in acetonitrile (10 ml.) was treated with n-propylisothiocyanate (0.74 g.) and the solution heated under reflux on the steam bath for 6 hours. Evaporation of the solvent gave a brown gum which on trituration with ether/EtOH gave 5-(3-[3-propylthioureido]pyrazol-1-yl)valeronitrile as a white solid (1.01 g.).

Workup

  1. temperaturethe solution heated
  2. temperatureunder reflux on the steam bath for 6 hours
  3. customEvaporation of the solvent
  4. customgave a brown gum which on trituration with ether/EtOH

Sources & evidence

ORD record
ord-c3c9ece329324edd977f1da7179c0efd
Source dataset
uspto-grants-1985_01
Patent number
US04496564

Reaction notes

Loading…