Benzenebutanamine → HCID 20430512, compound

HRID 2413162Notes

Reaction equation

HRID 2413162 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][C:13]1[N:18]=[CH:17][C:16]([CH2:19][C:20]2[C:21](=[O:28])[NH:22][C:23](SC)=[N:24][CH:25]=2)=[CH:15][CH:14]=1>N1C=CC=CC=1>[OH2:28].[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:23]2[NH:22][C:21](=[O:28])[C:20]([CH2:19][C:16]3[CH:17]=[N:18][C:13]([CH3:12])=[CH:14][CH:15]=3)=[CH:25][N:24]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 83242BenzenebutanamineHCID 127838272-methylthio-5-(2-methylpyrid-5-ylmethyl)-1H-pyrimid-4-one

Product 1

HCID 20430512HCID 20430512, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 4-phenylbutylamine (2.7 g), 5-(6-methyl-3-pyridylmethyl)-2-methylthio-4-pyrimidone (3.0 g) and dry pyridine (20 ml) was heated under reflux for 40 hours, and evaporated to dryness. Water was added to the residue and the pH of the mixture was adjusted to 7. The solid was filtered off and was recrystallized from aqueous ethanol to give 2-(4-phenylbutylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone hydrate m.p. 151°-152°.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 40 hours
  3. customevaporated to dryness
  4. additionWater was added to the residue
  5. filtrationThe solid was filtered off
  6. customwas recrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-9686ddb380a243b79ea31f2d185cce27
Source dataset
uspto-grants-1985_01
Patent number
US04496567

Reaction notes

Loading…