2-methylthio-5-(2-methylpyrid-5-ylmethyl)-1H-pyrimid-4-one → HCID 20430530, compound

Participants

Reaction Steps

2-Methoxy-5-(diethylaminomethyl)benzyl alcohol (British Patent Specification No. 594624) is treated with thionyl chloride to give the benzyl chloride and this is reacted with cysteamine and sodium ethoxide in ethanol to give 2-(2-methoxy-5-(diethylaminomethyl)benzylthio)ethylamine. This amine is heated under reflux for 40 hours in dry pyridine with 5-(6-methyl-3-pyridylmethyl)-2-methylthio-4-pyrimidone to give 2-[2-(2-methoxy-5-(diethylaminomethyl)benzylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Provenance & Evidence