5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one → HCID 20430487, compound

HRID 2413177Notes

Reaction equation

HRID 2413177 reaction equation
[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=1)[O:9][CH2:10][CH2:11][CH2:12][NH2:13].[N+](N[C:22]1[NH:27][C:26](=[O:28])[C:25]([CH2:29][C:30]2[CH:31]=[N:32][C:33]([CH3:36])=[CH:34][CH:35]=2)=[CH:24][N:23]=1)([O-])=O>N1C=CC=CC=1>[CH3:17][N:2]([CH3:1])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=1)[O:9][CH2:10][CH2:11][CH2:12][NH:13][C:22]1[NH:27][C:26](=[O:28])[C:25]([CH2:29][C:30]2[CH:31]=[N:32][C:33]([CH3:36])=[CH:34][CH:35]=2)=[CH:24][N:23]=1

Participants

4

Reactant 2

HCID 30183605-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-oneHCID 20430505HCID 20430505, compound

Product 1

HCID 20430487HCID 20430487, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Equimolar amounts of 3-(3-(2-(dimethylamino)ethoxy)phenoxy)propylamine and 2 -nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone are heated under reflux in dry pyridine for 24 hours to give 2-[3-(3-(2-dimethylaminoethoxy)phenoxy)propylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Sources & evidence

ORD record
ord-5dfca83ea3b1485a8d5fdacbca9083e5
Source dataset
uspto-grants-1985_01
Patent number
US04496567

Reaction notes

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