反应详情

Bromine (0.40 g) was added dropwise over 1 minute to a stirred solution of 1-acetyl-2,3-dimethylindole-5-carboxylic acid ethyl ester (0.65 g) in acetic acid (1.3 ml). After a few minutes a solid precipitated. The mixture was diluted with ca 5 ml. of ether and the solid was filtered off, washed with ether and dried to give 1-acetyl-2-bromomethyl-3-methylindole-5-carboxylic acid ethyl ester (0.38 g), m.p. 125°-130° . The product was unstable and was used directly in the next stage.

1. customAfter a few minutes a solid precipitated
2. additionThe mixture was diluted with ca 5 ml
3. filtrationof ether and the solid was filtered off
4. washwashed with ether
5. customdried