2-[4-(Benzyloxy)anilino]-5-methoxybenzoic acid → HCID 13371473, compound

HRID 2413276Notes

Reaction equation

HRID 2413276 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:17]=2C(O)=O)=[CH:11][CH:10]=1)C1C=CC=CC=1.C[Li]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:17]=2[C:9](=[O:8])[CH3:10])=[CH:11][CH:10]=1)[C:16]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:17]=1

Participants

3

Reactant 2

HCID 133714622-[4-(Benzyloxy)anilino]-5-methoxybenzoic acidHCID 178418348HCID 178418348, compound

Product 1

HCID 13371473HCID 13371473, compound

Procedure

1-[2-(4-Benzyloxyphenylamino)-5-methoxyphenyl]ethanone [XIII; R=5-CH3O, OR°=4-OCH2C6H5, R"=H] was prepared by reduction of 2-(4-benzyloxyphenylamino)-5-methoxybenzoic acid (Example 1A, part a) with methyllithium according to the procedure of Example 5, part (a), and obtained in the form of a yellow-orange powder, m.p. 80°-81.5° C. when recrystallized from toluene.

Workup

  1. customobtained in the form of a yellow-orange powder, m.p. 80°-81.5° C. when
  2. customrecrystallized from toluene

Sources & evidence

ORD record
ord-9794b4ef7f5a48b99c2836d4e036868a
Source dataset
uspto-grants-1985_01
Patent number
US04496590

Reaction notes

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