反应详情

To a suspension of 3.7 g of 2-(4-hydroxyphenylamino)-5- methoxybenzenemethanol (Example 1c) in 300 ml of methylene dichloride was added 32 g of silica treated sodium metaperiodate. The reaction mixture was stirred for two hours at room temperature, then filtered and washed with water and dried over anhydrous sodium sulfate. The solution was concentrated and the residue triturated with hexane to give 1.1 g of 4-(2-hydroxymethyl-4-methoxyphenylimino)-2,5-cyclohexadien-1-one, m.p. 87°-89° C.

1. additionwas added 32 g of silica
2. filtrationfiltered
3. washwashed with water
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationThe solution was concentrated
6. customthe residue triturated with hexane