HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Acetylamino-2-difluoromethyl-5-guanidinopentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Acetylamino-5-amino-2-difluoromethylpentanoic acid | HCID 19966338 | — |
| Reactant | [amino(sulfanyl)methylidene]-ethylazanium;hydrobromide | HCID 178419565 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-Acetylamino-2-difluoromethyl-5-guanidinopentanoic acid | HCID 178474775 | — |
Reaction Steps
To a solution of 2-acetylamino-5-amino-2-difluoromethylpentanoic acid (0.45 g) in 4 ml of 0.5 M aqueous sodium hydroxide is added 1.8 g of ethylthiouroniumhydrobromide. The pH of the solution is adjusted to 9 with a solution of sodium hydroxide and maintained at that pH for 24 hours. The reaction mixture is then neutralized to a pH of 7 with hydrochloric acid and 2-acetylamino-2-difluoromethyl-5-guanidinopentanoic acid is isolated by ion exchange chromatography on an Amberlite IR 120 resin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04496588 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-6913e961088d4df2bbe3663e31494f6a |
| Source note | uspto-grants-1985_01 |