HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ketorolac
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1,7-dicarboxylic acid | HCID 20430879 | — |
| Product | Ketorolac | HCID 3826 | — |
Reaction Steps
The acidic decarboxylation is conducted under mild conditions. For example, 5-benzoyl-7-hydroxycarbonyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-caboxylic acid is treated with refluxing trifluoroacetic acid to afford 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid. Other acids may also be used. For example, those listed below in Table I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04496741 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-23dad51471844ccdbd0ea3b2bf6f706e |
| Source note | uspto-grants-1985_01 |