HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → 7-Amino-3-(2-benzamido-thiazol-5-yl)-2-benzhydryloxycarbonyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 3-(2-Benzamidothiazol-5-yl)-2-benzhydryloxycarbonyl-7-t-butoxycarbonylamino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene | HCID 13175950 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 7-Amino-3-(2-benzamido-thiazol-5-yl)-2-benzhydryloxycarbonyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene | HCID 13175956 | 81.1% |
Reaction Steps
A solution of 3-(2-benzamido-thiazol-5-yl)-2-benzhydryloxycarbonyl-7-t-butoxycarbonylamino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (2.9 g) in acetonitrile (29 cc) is treated with methanesulphonic acid (2.9 cc) using the working method of Example 15. Crude 7-amino-3-(2-benzamido-thiazol-5-yl)-2-benzhydryloxycarbonyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (2 g) is obtained in the form of a yellow froth.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04496560 |
| Source dataset | uspto-grants-1985_01 |
| ORD ID | ord-7dd784caa00d4b9aa638bee904639569 |
| Source note | uspto-grants-1985_01 |