HCID 13175963, compound → HCID 13175969, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-(2-benzamido-thiazol-5-yl)-2-benzhydryloxycarbonyl-8-oxo-7-(thien-2-yl-acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (1.5 g) in a mixture of formic acid (43 cc) and distilled water (8 cc) is heated for 30 minutes at 60° C. and then diluted with distilled water (35 cc). The precipitate is filtered off, washed with 50% strength (by volume) formic acid (2×10 cc) and then with isopropyl ether (3×75 cc) and dried; 3-(2-benzamidothiazol-5-yl)-2-carboxy-8-oxo-7-(thien-2-yl-acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (1 g) is obtained in the form of a white solid.

Provenance & Evidence