Trifluoroacetic acid → HCID 13175970, compound

Participants

Reaction Steps

2-Benzhydryloxycarbonyl-7-t-butoxycarbonylamino-8-oxo-3-(2-phenyl-thiazol-5-yl)-5-thia-1-azabicyclo[4.2.0]-oct-2-ene (5.7 g) is treated with trifluoroacetic acid (57 cc) for 20 minutes at 20° C. and the reaction mixture is then concentrated to dryness under reduced pressure (0.2 mm Hg; 0.03 kPa) at 30° C. The residue is taken up in ethyl acetate (100 cc), which is evaporated under reduced pressure (30 mm Hg; 4 kPa) at 30° C. This residue is triturated with isopropyl ether (100 cc). The solid is filtered off, washed with isopropyl ether (3×50 cc) and dried under reduced pressure (0.2 mm Hg; 0.03 kPa) at 20° C. 7-Amino-2-carboxy-8-oxo-3-(2-phenyl-thiazol-5-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (3.3 g) is obtained in the form of an ochre solid.

Provenance & Evidence