Methanesulfonic Acid → HCID 20430453, compound

Participants

Reaction Steps

On treating 3-[2-(4-acetamido-phenyl)-thiazol-5-yl]-2-benzhydryloxycarbonyl-7-t-butoxycarbonylamino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (3.4 g) with methanesulphonic acid (3.4 cc) in acetonitrile (15 cc), in accordance with the working method described in Example 15, crude 7-amino-3-[2-(4-acetamido-phenyl)-thiazol-5-yl]-2-benzhydryloxycarbonyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (2.9 g) is obtained, and this is acylated with (thien-2-yl)-acetyl chloride (0.62 cc) in accordance with the working method described in Example 1. The crude product obtained is purified by crystallisation from acetonitrile (200 cc). 3-[2-(4-Acetamido-phenyl)-thiazol-5-yl]-2-benzhydryloxycarbonyl-8-oxo-7-[(thien-2-yl)-acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene (1.33 g) is obtained in the form of a beige crystalline powder.

Provenance & Evidence