Anisole → HCID 20430416, compound

Participants

Reaction Steps

Following the working method described in Example 4, 3-[2-(4-acetamido-phenyl)-thiazol-5-yl]-2-benzhydryloxycarbonyl-8-oxo-7-[(thien-2-yl)-acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene (1.5 g) is treated with formic acid (25 cc) and anisole (5 cc) at 50° C. for 20 minutes. 3-[2-(4-acetamido-phenyl)-thiazol-5-yl]-2-carboxy-8-oxo-7-[(thien-2-yl)-acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene (0.99 g) is obtained in the form of a yellow solid.

Provenance & Evidence