Methanesulfonic Acid → HCID 20430448, compound

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Reaction Steps

2-Benzhydryloxycarbonyl-7-t-butoxycarbonylamino-3-(2-methylthio-thiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (4 g) dissolved in acetonitrile (40 cc) is treated, at 25° C., with methanesulphonic acid (4 cc), in accordance with the working method of Example 15. Crude 7-amino-2-benzhydryloxycarbonyl-3-(2-methylthio-thiazol-5-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (3.3 g) is obtained in the form of an orange oil.

Provenance & Evidence