Anisole → HCID 86739894, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-benzhydryloxycarbonyl-7-(3,4-dichlorophenylthio)-acetamido-3-[2-(2-dimethylamino-ethylamino)-thiazol-5-yl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2ene (1.5 g), anisole (5 cc) and formic acid (25 cc) is stirred for 30 minutes at 50° C. The mixture is concentrated to dryness under reduced pressure (0.1 mm Hg; 0.013 kPa) and the residue is then taken up in ethanol (3×50 cc) and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 30° C. The solid obtained is washed with acetone (50 cc) and then with ethyl ether (50 cc). It is dried under reduced pressure (0.1 mm Hg; 0.013 kPa), giving 2-carboxy-7-(3,4-dichloro-phenylthio)-acetamido-3-[2-(2-dimethylamino-ethylamino)-thiazol-5-yl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (1 g) in the form of a yellow powder.

Provenance & Evidence