Methanesulfonic Acid → HCID 13319610, compound

Participants

Reaction Conditions

Reaction Steps

Methanesulphonic acid (0.3 cc) is added to a suspension of 2-benzhydryloxycarbonyl-7-t-butoxycarbonylamino-3-[2-(2-dimethylamino-ethylamino)-thiazol-5-yl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (0.3 g) in acetonitrile (3 cc). The yellow solution obtained is stirred at 23° C. for 5 minutes and is poured onto a mixture of a saturated sodium bicarbonate solution (50 cc) and ethyl acetate (50 cc). The organic phase is dried over anhydrous magnesium sulphate, filtered and concentrated under reduced pressure (20 mm Hg; 2.7 kPa). 7-Amino-2-benzhydryloxycarbonyl-3-[2-(2-dimethylamino-ethylamino)-thiazol-5-yl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene (0.25 g) is thus obtained in the form of a yellow froth.

Provenance & Evidence