HCID 86739897, compound → HCID 86739896, compound

Participants

Reaction Steps

A solution of 3-(2-acetylamino-thiazol-5-yl)-2-benzhydryloxycarbonyl-8-oxo-7-(thien-2-yl)-acetamido-5-oxa-1-azabicyclo[4.2.0]oct-2-ene (0.1 g) in formic acid (5 cc) is heated at 50° C. for 30 minutes, with stirring. The mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 50° C., and the residue is dissolved in ethanol (5 cc). The suspension obtained is stirred at 50° C. for 5 minutes and the solvent is evaporated under reduced pressure (30 mm Hg; 4 kPa) at 50° C.; this operation is repeated once, and the residue thus obtained is taken up in ethanol (2 cc). The solid in suspension yields, on filtration, 3-(2-acetylamino-thiazol-5-yl)-2-carboxy-8-oxo-7-(thien-2-yl)-acetamido-5-oxa-1-azabicyclo[4.2.0]oct-2-ene (12 mg) in the form of a beige powder.

Provenance & Evidence