反应详情

Allyloxyamine hydrochloride (0.72 g) and then a solution of sodium hydroxide (0.25 g) in water (3 ml) were added to a stirred mixture of 2-butyryl-3-hydroxy-5-mesitylcyclohex-2-en-1-one (1.78 g; 5.9 mmole) and 95% ethanol. The progress of the reaction was monitored using thin layer chromatography on silica gel (eluant dichloromethane). On completion of the reaction the ethanol was removed by evaporation using a rotary evaporator and the residue was extracted with dichloromethane. The organic extract was washed with aqueous 5% hydrochloric acid and then with water and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure using a rotary evaporator to give the product, 2-[1-(allyloxyimino)butyl]-3-hydroxy-5-mesitylcyclohex-2-en-1-one (1.6 g) as an oil.

1. customwas removed by evaporation
2. customa rotary evaporator
3. extractionthe residue was extracted with dichloromethane
4. extractionThe organic extract
5. washwas washed with aqueous 5% hydrochloric acid
6. dry with materialwith water and dried over anhydrous magnesium sulfate
7. customThe solvent was removed by evaporation under reduced pressure
8. customa rotary evaporator