Water → HCID 20155855, compound

Participants

Reaction Steps

The compound of Example 1 (500 mg, 1.06 mmoles) was taken up in a mixture of THF (10 ml), 1N NaOH (2.2 ml) and water (7.8 ml). The reaction mixture was stirred at room temperature for three hours, then concentrated in vacuo. The residue was taken up in water, filtered, acidified with dilute HCl and extracted with chloroform. The combined chloroform extracts were dried and concentrated in vacuo to afford the title compound which was recrystallized from ethyl acetate/hexane, m.p. 133°-135° (dec.).

Provenance & Evidence