Water → HCID 20155854, compound

Participants

Reaction Steps

The compound of Example 3 (430 mg, 0.851 mmoles) was taken up in a mixture of THF (10 ml), 1N NaOH (1.8 ml) and water (8.2 ml). The reaction mixture was stirred at room temperature under nitrogen for two hours. The THF was then removed in vacuo and the residue was diluted with water and filtered. The aqueous solution was acidified with dilute HCl and extracted with chloroform. The combined chloroform extracts were dried and concentrated in vacuo to afford the title compound which was recrystallized from ethyl acetate/hexane, m.p. 171°-173°.

Provenance & Evidence