Water → HCID 13361851, compound

Participants

Reaction Steps

1.4 g of 6-hydroxy-2-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline, 2.1 g of (2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate and 0.3 g of tetrabutylammonium bromide are heated to reflux, with vigorous stirring, for 9 hours in a mixture of 40 ml of toluene and 10 ml of 50% strength sodium hydroxide solution. After cooling, 50 ml of water are added, and the organic phase is washed with water, dried over magnesium sulfate and evaporated in a rotary evaporator. The crude product is purified by column chromatography on silica gel using a mixture of ethyl acetate and methanol 19:1. 2.2 g of a colorless oil (76% of theory) which crystallizes on trituration with diethyl ether are obtained. Melting point: 121°-122°.

Provenance & Evidence