反应详情

5.0 g of 6-hydroxy-1,2,3,4-tetrahydroisoquinoline are converted into the bisacetyl compound using acetic anhydride or acetyl chloride/triethylamine, and, without purification, this compound is heated under reflux for 6 hours with 10 ml of diethylamine in 50 ml of ethanol. The mixture is evaporated in vacuo in a rotary evaporator, and the residue is chromatographed on silica gel using ethyl acetate/methanol in the ratio 9:1. A yellow oil which crystallizes on trituration with diethyl ether is obtained. Yield: 5.2 g (78% of theory), melting point: 129°-130°.

1. customwithout purification
2. temperaturethis compound is heated
3. temperatureunder reflux for 6 hours with 10 ml of diethylamine in 50 ml of ethanol
4. customThe mixture is evaporated in vacuo in a rotary evaporator
5. customthe residue is chromatographed on silica gel
6. customA yellow oil which crystallizes on trituration with diethyl ether
7. customis obtained