Ethylamine → HCID 13366331, compound

HRID 2413508Notes

Reaction equation

HRID 2413508 reaction equation
[CH2:1]([O:3][CH:4]([O:14][CH2:15][CH3:16])[CH2:5][NH:6][C:7](=[O:13])[C:8]([O:10]CC)=O)[CH3:2].[CH2:17]([NH2:19])[CH3:18]>C(O)C>[CH2:17]([NH:19][C:8]([C:7]([NH:6][CH2:5][CH:4]([O:3][CH2:1][CH3:2])[O:14][CH2:15][CH3:16])=[O:13])=[O:10])[CH3:18]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 13372756HCID 13372756, compound

Product 1

HCID 13366331HCID 13366331, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 20.0 g of ethyl N-(2,2-diethoxyethyl)oxamate in 60 ml of ethanol was added 6.1 ml of 70% by weight aqueous ethylamine solution, and the mixture was subjected to reaction at room temperature for 1 hour. After the completion of the reaction, the precipitated crystals were collected by filtration and recrystallized from ethanol to obtain 17.0 g (yield: 85.1%) of N-ethyl-N'-(2,2-diethoxyethyl)oxamide having a melting point of 131°-132° C.

Workup

  1. customthe mixture was subjected to reaction at room temperature for 1 hour
  2. customAfter the completion of the reaction
  3. filtrationthe precipitated crystals were collected by filtration
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-12622ecad7c3439c9434e193b2c3430b
Source dataset
uspto-grants-1988_01
Patent number
US04717767

Reaction notes

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