4,7-Dichloroquinazoline → HCID 58451111, compound

HRID 241351Notes

Reaction equation

HRID 241351 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:20])[CH2:13][CH2:12][N:11]([CH:14]3[CH:18]([OH:19])[CH2:17][NH:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl[C:22]1[C:31]2[C:26](=[CH:27][C:28]([Cl:32])=[CH:29][CH:30]=2)[N:25]=[CH:24][N:23]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:20])[CH2:13][CH2:12][N:11]([C@@H:14]3[C@@H:18]([OH:19])[CH2:17][N:16]([C:22]4[C:31]5[C:26](=[CH:27][C:28]([Cl:32])=[CH:29][CH:30]=5)[N:25]=[CH:24][N:23]=4)[CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2418814,7-DichloroquinazolineHCID 66967964HCID 66967964, compound

Product 1

HCID 58451111HCID 58451111, compound

Procedure

The title compound was prepared following general procedures described above from 4-(4-Chlorophenyl)-1-(4-hydroxy-pyrrolidin-3-yl)-piperidin-4-ol and 4,7-dichloroquinazoline. 1H-NMR (300 MHz, DMSO): δ1.57 (2H, m), 1.90 (2H, m), 2.60-2.70 (3H, m), 2.96 (2H, m), 3.70 (1H, m), 3.85 (1H, m), 4.10 (2H, m), 4.36 (1H, m), 4.90 (1H, s), 5.32 (1H, d), 7.40 (4H, dd), 7.48 (1H, m), 7.73 (1H, d), 8.30 (1H, d), 8.45 (1H, s). Retention Time (LC, method, AA standard): 1.48 min. MS (M+H+): 459.

Workup

  1. custom1.48 min

Sources & evidence

ORD record
ord-5e546c92ac594f8bb657f8943fb92754
Source dataset
uspto-grants-2014_02
Patent number
US08648197B2

Reaction notes

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