Sulfuric Acid → 2-(2-Benzothiazolylthio)propanamide

HRID 2413533Notes

Reaction equation

HRID 2413533 reaction equation
[SH:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[C:11]([NH2:15])(=[O:14])[CH:12]=[CH2:13].S(=O)(=O)(O)O>>[S:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[S:1][CH:12]([CH3:13])[C:11]([NH2:15])=[O:14]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 6579AcrylamideHCID 178418395HCID 178418395, compound

Product 1

HCID 48148732-(2-Benzothiazolylthio)propanamide

Procedure

A finely powdered mixture of 16.8 g of 2-mercaptobenzothiazole and 7.5 g of acrylic amide is added at 45°-50° in the course of 1 hour to 100 ml 70% sulfuric acid, with stirring. After a further hour at 45°-50°, the rection mixture is poured into ice water. The precipitate is filtered off, washed with water and dried. The obtained 2-(benzthiazol-2-ylthio)-propionic acid amide is recrystallized from ethylacetate and melts at 144°-145°.

Workup

  1. waitAfter a further hour at 45°-50°
  2. filtrationThe precipitate is filtered off
  3. washwashed with water
  4. customdried
  5. customThe obtained 2-(benzthiazol-2-ylthio)-propionic acid amide is recrystallized from ethylacetate and melts at 144°-145°

Sources & evidence

ORD record
ord-23b9c971c7954a35a528effa58bb9dfa
Source dataset
uspto-grants-1988_01
Patent number
US04719036

Reaction notes

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