HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 67362053, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | HCID 67361589 | HCID 67361589 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 67362053 | HCID 67362053 | — |
Reaction Steps
Under argon, 2.0 g of 15α-acetoxy-18-methyl-4-estrene-3,17-dione in 60 ml of dioxane is agitated at room temperature for 20 hours with 6 ml of triethyl orthoformate and 40 mg of p-toluenesulfonic acid. After adding 2 ml of pyridine, the mixture is diluted with ether, washed with water, and dried. The crude product is recrystallized from acetone/hexane. Yield: 1.6 g of 15α-acetoxy-3-ethoxy-18-methyl-3,5-estradien-17-one. Melting point: 202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04719054 |
| Source dataset | uspto-grants-1988_01 |
| ORD ID | ord-b3aa82fe677d4f7ba0235dd4265c371f |
| Source note | uspto-grants-1988_01 |