Ethyl 3-(4-benzyloxy-3-methylphenyl)-3-oxopropionate → 1-(4-Hydroxy-3-methylphenyl)-3-[3-methyl-6-(trifluoromethyl)benzothiophen-2-yl)propan-1-one
Reaction equation
[CH3:1][C:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[CH:10][C:5]=2[S:4][C:3]=1[CH2:15]O.C([O:24][C:25]1[CH:30]=[CH:29][C:28]([C:31](=[O:38])[CH2:32]C(OCC)=O)=[CH:27][C:26]=1[CH3:39])C1C=CC=CC=1>>[OH:24][C:25]1[CH:30]=[CH:29][C:28]([C:31](=[O:38])[CH2:32][CH2:15][C:3]2[S:4][C:5]3[CH:10]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:8]=[CH:7][C:6]=3[C:2]=2[CH3:1])=[CH:27][C:26]=1[CH3:39]Participants
3
Procedure
The titled compound was prepared from the above-mentioned 3-methyl-6-(trifluoromethyl)benzothiophen-2-ylmethanol [WO 2005077926] (906 mg, 3.68 mmol) and Ethyl 3-(4-benzyloxy-3-methylphenyl)-3-oxopropionate (1.14 g, 3.65 mmol) in a procedure similar to that of Example 1 (1) as a brown powder (680 mg, yield 49%).
Sources & evidence
- ORD record
- ord-7178a145461e4c2c82d007310a729b96
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08648208B2
Reaction notes
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