HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenylacetic acid → 2951-94-2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenylacetic acid | HCID 14533 | — |
| Reactant | 4-Cyanophenylacetic acid | HCID 79587 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2951-94-2 | HCID 13799938 | 63% |
Reaction Steps
The p-aminophenylacetic acid described in Example 1 is converted into p-cyanophenylacetic acid by diazotisation in the manner described in J. Chem. Soc., 1941, 745, the yield being 47% of theory; m.p. 138°-141° C. It is then hydrogenated in the presence of platinum catalyst in hydrochloric acid solution to give 4-aminomethylcyclohexylacetic acid; yield 63% of theory; m.p. 120-123° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04719203 |
| Source dataset | uspto-grants-1988_01 |
| ORD ID | ord-3ef7d7ccfe7449e29204946a323c0f56 |
| Source note | uspto-grants-1988_01 |