HCID 13799941, compound → HCID 54521405, compound

Participants

Reaction Steps

From the cis-trans mixture of 3-(2-acetylaminocyclohexyl)-propionic acid described in Example 10, by recrystallisation from water there is obtained the pure cis-compound (yield 32% of theory; m.p. 131°-133° C.), the reaction of which with phosphorus trichloride/phosphorous acid takes place analogously to Example 1. The course of the splitting off of the acetyl radical by heating in hydrochloric acid is monitored by means of thin layer electrophoresis.

Provenance & Evidence