HCID 13799966, compound → HCID 131715426, compound

Participants

Reaction Steps

Starting from 3-(2-acetylaminocyclohexyl)-1-hydroxypropane-1,1-diphosphonic acid, the acetyl radical is completely eliminated by heating to 100° C. for 70 hours in 6N hydrochloric acid. The diphosphonic acid is purified by chromatographing on Amberlite IR-120 (H+ form) to give 3-(2-aminocyclohexyl)-1-hydroxypropane-1,1-diphosphonic acid sesquihydrate in the form of a cis, trans mixture (ratio as in the starting material). Yield 23% of theory; m.p. 163° C., foaming up; Mrel =0.31.

Provenance & Evidence