HCID 13799191, compound → HCID 20155385, compound

Participants

Reaction Steps

1.0 g of methyltriphenylphosphoniumbromide+sodium amide (condition-ylide) in 8 ml of absolute tetrahydrofuran is stirred at room temperature under argon for 15 minutes. To it is added 500 mg of 5-benzyloxy-4-methoxymethyl-9-tosyl-beta-carboline-3-carbaldehyde and the reaction mixture is refluxed for 4 hours. After evaporation of the solvent, the residue is chromatographed over silica gel with cyclohexane/acetic acid=8+2 as eluant. 0.153 mg of 5-benzyloxy-4-methoxymethyl-9-tosyl-3-vinyl-beta-carboline with a melting point of 141°-143° C. is obtained.

Provenance & Evidence