HCID 18611253, compound → HCID 178462019, compound

HRID 2413722Notes

Reaction equation

HRID 2413722 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]([NH:11][C@H:12]([C:14]([N:16]2[CH2:30][CH2:29][CH2:28][C@H:17]2[C:18]([N:20]2[CH2:27][CH2:26][CH2:25][C@H:21]2[C:22]([OH:24])=[O:23])=[O:19])=[O:15])[CH3:13])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:31][C@H:32]([C:40]([OH:42])=[O:41])[CH2:33][CH2:34][CH2:35][NH:36][C:37](=[NH:39])[NH2:38]>O>[NH2:31][C@H:32]([C:40]([OH:42])=[O:41])[CH2:33][CH2:34][CH2:35][NH:36][C:37](=[NH:38])[NH2:39].[C:1]1([CH2:7][C:8]#[C:9][NH:11][C@H:12]([C:14]([N:16]2[CH2:30][CH2:29][CH2:28][C@H:17]2[C:18]([N:20]2[CH2:27][CH2:26][CH2:25][C@H:21]2[C:22]([OH:24])=[O:23])=[O:19])=[O:15])[CH3:13])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 18611253HCID 18611253, compoundHCID 178418600HCID 178418600, compound

Product 1

HCID 178462019HCID 178462019, compoundYield 101.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-(3-phenylpropionyl)-L-alanyl-L-prolyl-L-proline (1.00 g, 2.41 m mole) was dissolved in a solution of L-arginine (0.42 g, 2.41 m mole) in water (30 ml), and the thus obtained solution was freeze-dried to give N-(3-phenylpropinyl)-L-alanyl-L-prolyl-L-proline L-arginine salt (1.40 g).

Workup

  1. customthe thus obtained solution was freeze-dried

Sources & evidence

ORD record
ord-37a9ee30c5fc4bb2aed7265888f2b826
Source dataset
uspto-grants-1988_01
Patent number
US04719200

Reaction notes

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