HCID 53822454, compound → HCID 54378965, compound

Participants

Reaction Steps

N-ethanesulfonyl-L-alanyl-L-prolyl-L-proline benzylester (2.00 g, 4.29 m mole) was dissolved in a mixture of methanol (10 ml) and water (10 ml), and then hydrogen gas was passed through the solution in the presence of 5% palladium carbon for 1.5 hours at room temperature. Cellite was added to the reaction solution and the solution was filtered and this operation was repeated again. The catalyst was completely removed and the filtrate was concentrated under reduced pressure. The thus produced crystals were obtained by filtration, washed sufficiently with ethyl acetate, and then dried under reduced pressure to give white crystals of N-ethanesulfonyl-L-alanyl-L-prolyl-L-proline (1.17 g).

Provenance & Evidence