HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-Acetylpyridine 4-(2-morpholinoethyl)thiosemicarbazone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Acetylpyridine | HCID 14286 | — |
| Reactant | 3-Amino-1-(2-(morpholin-4-yl)ethyl)thiourea | HCID 736209 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Acetylpyridine 4-(2-morpholinoethyl)thiosemicarbazone | HCID 54402859 | — |
Reaction Steps
A mixture of 6.00 g (0.0294 mole) of 4-(2-morpholinoethyl)thiosemicarbazide, 3.91 g (0.0323 mole) of 2-acetylpyridine, 20 mL of 95% ethanol, and 0.4 mL of glacial acetic acid was heated under reflux for 1.25 hours. The mixture then stood overnight at room temperature. Colourless crystals were collected and recrystallised from 40 mL of 95% ethanol; yield 7.81 g (86%) of pale yellow crystals of 2-acetylpyridine 4-(2-morpholinoethyl)thioseicarbazone, mp 167.5°-169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04719221 |
| Source dataset | uspto-grants-1988_01 |
| ORD ID | ord-a7071a5459f34bbc99fc2494dadebae9 |
| Source note | uspto-grants-1988_01 |