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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241374Generated: October 31, 2026

Methyl 3-(4-acetyl-2-methylphenyl)acrylate → Methyl 3-[4-[3-[3-isobutyl-6-(trifluoromethyl)benzothiophen-2-yl]propenoyl]-2-methylphenyl]acrylate

https://huagongshe.com/reaction/241374

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-(4-acetyl-2-methylphenyl)acrylateHCID 66883900—
Reactant3-Isobutyl-6-(trifluoromethyl)benzothiophen-2-carboxaldehydeHCID 86652866—
ProductMethyl 3-[4-[3-[3-isobutyl-6-(trifluoromethyl)benzothiophen-2-yl]propenoyl]-2-methylphenyl]acrylateHCID 66883436—

Reaction Steps

The titled compound was prepared from the above-mentioned 3-isobutyl-6-(trifluoromethyl)benzothiophen-2-carboxaldehyde (250 mg, 0.873 mmol) and methyl 3-(4-acetyl-2-methylphenyl)acrylate (191 mg, 0.875 mmol) in a procedure similar to that of Example 7 (1) as a yellow crystal (250 mg, yield 71%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648208B2
Source datasetuspto-grants-2014_02
ORD IDord-4700a762c57740a986fcae5b3eccc7f9
Source noteuspto-grants-2014_02