反应详情

A solution of glycylglycinamide (0.5 g) and acetaldehyde (0.4 ml) in methanol (5 ml) was stirred at room temperature for 8 hours. Evaporation of the solvent gave a residue which was chromatographed on a silica gel column (eluant dichloromethane/methanol 75:25). The selected fractions were collected, evaporated to give the title compound (Rf=0.3, dichloromethane/methanol 7:3, silica gel plates). Mass spectrum (E.I., 70 eV, 1.5 mA), m/z=142 (M+ -CH3), 99.

1. customEvaporation of the solvent
2. customgave a residue which
3. customwas chromatographed on a silica gel column (eluant dichloromethane/methanol 75:25)
4. customThe selected fractions were collected
5. customevaporated