Methyl 3-(4-acetyl-2-methylphenyl)acrylate → HCID 66883934, compound

HRID 241375Notes

Reaction equation

HRID 241375 reaction equation
[CH:1]([C:4]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:7]=2[S:6][C:5]=1[CH:17]=O)([CH3:3])[CH3:2].[C:19]([C:22]1[CH:27]=[CH:26][C:25]([CH:28]=[CH:29][C:30]([O:32][CH3:33])=[O:31])=[C:24]([CH3:34])[CH:23]=1)(=[O:21])[CH3:20]>>[CH:1]([C:4]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:7]=2[S:6][C:5]=1[CH:17]=[CH:20][C:19]([C:22]1[CH:27]=[CH:26][C:25]([CH:28]=[CH:29][C:30]([O:32][CH3:33])=[O:31])=[C:24]([CH3:34])[CH:23]=1)=[O:21])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 66883900Methyl 3-(4-acetyl-2-methylphenyl)acrylateHCID 86652867HCID 86652867, compound

Product 1

HCID 66883934HCID 66883934, compound

Procedure

The titled compound was prepared from the above-mentioned 3-isopropyl-6-(trifluoromethyl)benzothiophen-2-carboxaldehyde (215 mg, 0.790 mmol) and methyl 3-(4-acetyl-2-methylphenyl)-acrylate (172 mg, 0.788 mmol) in a procedure similar to that of Example 7 (1) as a yellow crystal (259 mg, yield 69%).

Sources & evidence

ORD record
ord-fb2a73481152405ea010a3541d7c37e5
Source dataset
uspto-grants-2014_02
Patent number
US08648208B2

Reaction notes

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