Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

To a ice-cooled solution of benzhydryl 7-tertbutoxycarbonylamino-3-[2-(1-methyl-2-pyridinio)thiovinyl]-3-cephem-4-carboxylate iodide (trans isomer) (5.0 g) in methylenechloride (15 ml) and anisole (20 ml) was dropwise added to trifluoroacetic acid (40 ml). The mixture was stirred under same condition for 2 hours. The reaction mixture was poured into diisopropylether and the resultant precipitate was collected by filtration to give trifluoroacetic acid salt of 7-amino-3-[2-(1-methyl-2-pyridinio)thiovinyl]-3-cephem-4-carboxylate hydriodide (trans isomer) (3.9 g).

Provenance & Evidence