HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2413832Generated: October 30, 2026
Diethyl (ethoxymethylene)malonate → HCID 12733838, compound
https://huagongshe.com/reaction/2413832
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O) | HCID 12733834 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 12733838 | HCID 12733838 | 94.8% |
Reaction Steps
A mixture of 26.56 g (0.1579 mol) of 2-(N-acetylamino)-4-amino-1-fluorobenzene, 35.89 ml (0.1776 mol) of diethyl ethoxymethylenemalonate, and 30 ml of toluene is stirred at 130° C. for 3 hours. After cooling, the precipitate which forms is triturated with ether to yield 50.64 g (94.8%) of title compound as a white solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04719302 |
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| Source dataset | uspto-grants-1988_01 |
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| ORD ID | ord-3b84956d50544f2294352dd19062bad9 |
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| Source note | uspto-grants-1988_01 |
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