HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → HCID 70418167, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | N-(3-amino-4-fluorophenyl)acetamide | HCID 345389 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 70418167 | HCID 70418167 | 86.1% |
Reaction Steps
A mixture of 1.9 g (0.0113 mol) of 4-(N-acetylamino)-2-amino-1-fluorobenzene, 2.6 ml (2.78 g/0.0129 mol) of diethyl ethoxymethylenemalonate, and 4 ml of toluene is stirred at reflux for three hours, then allowed to cool to ambient temperature. The resulting precipitate is triturated with ether to give 3.29 g (84%) of title compound:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04719302 |
| Source dataset | uspto-grants-1988_01 |
| ORD ID | ord-7635629a519a49be9fa5845d5944e926 |
| Source note | uspto-grants-1988_01 |