Water → HCID 14126411, compound

HRID 2413857Notes

Reaction equation

HRID 2413857 reaction equation
[CH:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1.O>N1C=CC=CC=1>[C:18]([O:16][C:13]1[CH:14]=[CH:15][C:10]([C:8](=[O:9])[CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:11][CH:12]=1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1

Participants

5

Reactant 3

HCID 962WaterHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 12505087HCID 12505087, compound

Product 1

HCID 14126411HCID 14126411, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Conditions

Temperature
40 °C

Procedure

11 g (50 mmol) of p-cyclohexylacetylphenol and 9.6 g (54 mmol) of nicotinic acid chloride hydrochloride was mixed with 160 ml of dry pyridine and stirred for 8 hours at 40° C. Subsequently, water (66 ml) was added drop by drop until the solution was turbid. The solution was placed in the ice bath, the precipitate sucked off, freed from pyridine by washing with water and dried.

Workup

  1. washby washing with water
  2. customdried

Sources & evidence

ORD record
ord-b1f3639a3c9e4d40a66f01e51200592d
Source dataset
uspto-grants-1988_01
Patent number
USRE032581

Reaction notes

Loading…