Dimethyl Sulfide → HCID 18611327, compound

Participants

Reaction Steps

Ozone is passed through a solution of 6.2 g of 2-[4-acetoxy-(3R)-3-[1(R)-fluorethyl]-2-oxoazetidine-1-yl]-3-methyl-2-butenoic acid.benzhydrylester at -78° until a permanent blue colour is achieved. The excess ozone is drive out with nitrogen and 1.75 g of dimethylsulphide added. The reaction mixture is allowed to rise to room temperature. The solvent is evaporated on a rotary evaporator, the residue taken up in 100 ml of methanol and after addition of 2 drops of triethylamine stirred for 2 hours. After renewed concentration the residue is chromatographed on silica gel (dichloromethane/ethylacetate=10/3) to obtain the oily title compound.

Provenance & Evidence