HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2413891Generated: November 3, 2026
Acetyl chloride → N-[(5-Acetyl-2-thienyl)methyl]acetamide
https://huagongshe.com/reaction/2413891
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | N-[(thiophen-2-yl)methyl]acetamide | HCID 30617 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | N-[(5-Acetyl-2-thienyl)methyl]acetamide | HCID 7131592 | — |
Reaction Steps
To a solution of 40 g of 2-acetylaminomethylthiophene and 30.3 g of acetylchloride in 600 ml of dichloroethane is added a small portion of 76.3 g of anhydrous aluminum chloride under cooling at 5°-10° C. After the mixture is stirred at 10° C. for 30 minutes and poured into ice-cold water, the precipitated crystals are collected by filtration to give 2-acetylaminomethyl-5-acetylthiophene, melting F- at 129°-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04720493 |
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| Source dataset | uspto-grants-1988_01 |
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| ORD ID | ord-6a711cea372044ecb528741d3b543c97 |
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| Source note | uspto-grants-1988_01 |
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