Bromine → HCID 20154322, compound

HRID 2413892Notes

Reaction equation

HRID 2413892 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[S:7][C:8]([C:11](=[O:13])[CH3:12])=[CH:9][CH:10]=1)(=[O:3])[CH3:2].[Br:14]Br>C(Cl)(Cl)Cl>[C:1]([NH:4][CH2:5][C:6]1[S:7][C:8]([C:11](=[O:13])[CH2:12][Br:14])=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24408BromineHCID 7131592N-[(5-Acetyl-2-thienyl)methyl]acetamide

Product 1

HCID 20154322HCID 20154322, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 40.3 g of 2-acetylaminomethyl-5-acetylthiophene in 500 ml of chloroform is added dropwise bromine under cooling with ice at 5°-10° C., and the mixture is stirred at room temperature for 30 minutes. After the resulting mixture is washed with water, dried over anhydrous magnesium sulfate and concentrated, the residue is recrystallized from ethanol to give 2-acetylaminomethyl-5-bromoacetylthiophene, melting at 129°-131° C.

Workup

  1. temperatureunder cooling with ice at 5°-10° C.
  2. washAfter the resulting mixture is washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated
  5. customthe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-28bb7dea11d641d7ba4c3d1b666db1b2
Source dataset
uspto-grants-1988_01
Patent number
US04720493

Reaction notes

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