Ethyl Nicotinate → HCID 20154217, compound

Participants

Reaction Steps

To a solution of 4.0 g of 2-amino-4-(5-aminomethyl-2-thienyl)thiazole in 100 ml of ethanol is added 2.85 g of ethyl nicotinate, and refluxed for 8 hours. After the reaction mixture is cooled with ice, the precipitated crystals are collected by filtration and recrystallized from dimethylformamide to give 2-amino-4-(5-nicotinoylaminomethyl-2-thienyl)thiazole, melting at 240°-241° C. with decomposition.

Provenance & Evidence